ynzC [2019-07-02 10:07:51]

unknown

locus: BSU17880

pI: 10.28

mw: 8.67 kDa

protein length: 77 aa

gene length: 234 bp

function: unknown

product: unknown

essential: no

synonyms

Genomic Context

categories

• [category|SW 6|Groups of genes] → [category|SW 6.7|Proteins of unknown function]

Gene

Coordinates: 1,919,459 1,919,692

Phenotypes of a mutant

• increased sensitivity to DNA-damaging agents [Pubmed|23728628]

The protein

Protein family

• UPF0291 family (according to Swiss-Prot)

Structure

• [PDB|2HEP] (NMR), [PDB|3BHP]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|7BF591DCDC9635C605D76135481A8A9DB63EE861|yneA]-[gene|67074435B8FDA85C8ED4D8C4ECE3580C4EDFBF2A|yneB]-[gene|5BFD552F8A467C8D95FABE87CC8C5E7F04114886|ynzC]
  description: [Pubmed|12581363]

  regulatory mechanism

  • [protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]: repression, [Pubmed|12581363], in [regulon|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA regulon]

  regulation

  • induced by DNA damage ([protein|D267AF38B0CF107042326E9B8F3DD3C9C85840E4|LexA]) [Pubmed|12581363]

  additional information

  • YneA is rapidly degraded by extracellular proteases ([protein|5ED8301B9681FDD5171A9344A971E891493A6558|CtpA]) [PubMed|29979679,20400548]

Biological materials

Mutant

• BKE17880 ([gene|5BFD552F8A467C8D95FABE87CC8C5E7F04114886|ynzC]::erm trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKE17880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTAAACTCCTTTATTG, downstream forward: _UP4_TAATATAAGAGGAATACGGC
• BKK17880 ([gene|5BFD552F8A467C8D95FABE87CC8C5E7F04114886|ynzC]::kan trpC2) available at [http://www.bgsc.org/getdetail.php?bgscid=BKK17880 BGSC], [Pubmed|28189581], upstream reverse: _UP1_CATGTTAAACTCCTTTATTG, downstream forward: _UP4_TAATATAAGAGGAATACGGC

References

• 12581363,16267290,23728628